MOLECULAR BASIS OF THE FUNCTIONING OF THE CYTOKINE SYSTEM AND ANTICYTOKINE THERAPY FOR RHEUMATOID ARTHRITIS
Keywords:
rheumatoid arthritis, cytokines, gene polymorphism, interleukins, tumor necrosis factor (TNFα), monoclonal antibodies.Abstract
The cytokine system is a universal, polymorphic, regulatory network of mediators designed to control the processes of proliferation, differentiation and functional activity of cellular elements in the hematopoietic, immune and other homeostatic systems of the body. One of the important issues in the pathogenesis of rheumatoid arthritis (RA) is the role of innate immune mechanisms in the development of autoimmune inflammation. The purpose of the study is to highlight the role of cytokines in the pathogenesis and improve anti-cytokine therapy. The material for the study was DNA samples from RA patients and healthy individuals of the therapeutic department No. 1 of the multidisciplinary clinic No. 1 of Samara State Medical University. The patient group consisted of 49 people aged 25-45 years and the control group, 71 practically healthy individuals. It has been established that the cytokine system is a polymorphic structure and in the formation of its polymorphism such a mechanism as allelic polymorphism is important. The presented results of clinical and laboratory studies show the development of torpidity to methotrexate therapy in subgroups of patients in both groups. Thus, the use of anti-cytokine therapy is a major advance in the treatment of rheumatoid arthritis.
References
Prashant kumar , babamuradova z. b., shavazi n. n. of the efficacy and safety of biological agents assessment in rheumatoid arthritis //journal of advanced medical and dental sciences research. – 2021. – vol. 9. – no. 6. – p. 26-31.
Babamuradova Z. b., shavazi n. n. the role of angiogenic growth factors in the pathogenesis of preterm labor in pregnant women on the background of undifferentiated connective tissue dysplasia with mitral valve prolapse // Journal of Cardiorespiratory Research. – 2022. – vol. 3. – No. 2.
Nasonova V.A. Handbook of rheumatology: 2nd ed. − L., Medicine, 2013, p. 25.
Shodikulova G. Z., Vokhidov Zh. Zh. MODERN VIEWS ON DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS (REVIEW OF LITERATURE) //THE THEORY OF RECENT SCIENTIFIC RESEARCH IN THE FIELD OF PEDAGOGY. – 2023. – T. 1. – No. 6. – pp. 101-112.
Shodikulova G. Z., Shonazarova N. Kh., Sheranov A. M. CHARACTERISTICS OF COMORBID RHEUMATOID ARTHRITIS AND HYPOTHYROIDIS // Achievements of Science and Education. – 2022. – No. 3 (83). – pp. 88-91
Atamas S.P., White B. // Clin. Diagn. Lab. Immunol. − 2019. − Vol. 6, No. 5. − P. 658-659.
Ayroldi E., D'Adamio F., Zollo O., et al. // Blood. − 2019. − Vol. 94, No. 10.− P. 3456-3467.
Cascino I., Papoff G., Eramo A. et al. // Frontiers in Bioscience. − 1996. − Vol. 1. − P. 12-18.
Chabaud M., Fossiez F., Taupin J.L., et al. // J Immunol. − 2018. − Vol. 161. − P. 409-414
Chabaud M., Garnero P., Dayer J.M., et al.// Cytokine. − 2020. − Vol. 12. - P. 1092-1099.
Cheng J., Zhou T., Liu C. et al. // Science. − 1994. − Vol. 263. - P. 1759-1762.
Chilton P.M., Fernandez-Botran R. // Cell. Immunol. − 1997. − Vol. 180, No. 2. − P. 104-115.
Corrigall V.M., Panayi G.S.// Crit Rev Immunol. − 2022. − Vol. 22, No. 4. − P.281-93.
Dudler J., Renggli-Zulliger N., Busso N., et al. // Ann Rheum Dis. − 2020. − Vol. 59. - P. 529-532.
Eisenberg S.P., Evans R.J., Arend W.P., et al. // Nature - 1990. - Vol. 343, No. 6256. − P. 341-346.
Fabris M., Di Poi E., Sacco S., et al. // Reumatismo. − 2012. − Vol. 54, no. 1. − P.19-26.
Feldman M., Brennan F., Maini R.N. // Amgen Inc. − 2016. − Vol. 14. − P.397-440.
Grasso L., Huang M., Sullivan C.D., et al. // J. Biol. Chem. − 1998. − Vol. 273, No. 37. − P. 24016-24024.
Heaney M.L., Vera J.C., Raines M.A. et al. // PNAS. − 1995. − Vol. 92, No. 6. − 2365-2369.
Jovanovic D.V., Martel-Pelletier J., Di Battista J.A., et al. // Arthritis Rheum. − 2020. − Vol. 43. - P. 1134-1144.
Katsikis P.D., Chu C-Q., Brennan F.M., et al.// J. Exp Med. − 2014. − Vol. 179. - P. 1517-1527.
Kestler D.P., Agarwal S., Cobb J. et al. // Blood. − 1995. − Vol. 86, no. 12. − P. 4559-4567.
Lazarus M., Hajeer A.H., Turner D., et al. // J. Rheumatol. − 2017. − Vol.24. − P.2314-7
Morita Y., Yamamura M., Kawashima M., et al. // Arthritis Rheum. − 2019. − Vol. 42. - P. 1508-1516.
