MOLECULAR BASIS OF THE FUNCTIONING OF THE CYTOKINE SYSTEM AND ANTICYTOKINE THERAPY FOR RHEUMATOID ARTHRITIS

Authors

  • Babamuradova Zarrina Bakhtiyarovna Prashant Kumar FACULTY MD General Medicine Samarkand State Medical University Samarkand, Uzbekistan SCIENTIFIC SUPERVISOR:
  • Babamuradova Zarrina Bakhtiyarovna (Head of the Department of Internal diseases of pediatric faculty, Ph.D., Associated professor)

Keywords:

rheumatoid arthritis, cytokines, gene polymorphism, interleukins, tumor necrosis factor (TNFα), monoclonal antibodies.

Abstract

The cytokine system is a universal, polymorphic, regulatory network of mediators designed to control the processes of proliferation, differentiation and functional activity of cellular elements in the hematopoietic, immune and other homeostatic systems of the body.  One of the important issues in the pathogenesis of rheumatoid arthritis (RA) is the role of innate immune mechanisms in the development of autoimmune inflammation.  The purpose of the study is to highlight the role of cytokines in the pathogenesis and improve anti-cytokine therapy.  The material for the study was DNA samples from RA patients and healthy individuals of the therapeutic department No. 1 of the multidisciplinary clinic No. 1 of Samara State Medical University.  The patient group consisted of 49 people aged 25-45 years and the control group, 71 practically healthy individuals.  It has been established that the cytokine system is a polymorphic structure and in the formation of its polymorphism such a mechanism as allelic polymorphism is important.  The presented results of clinical and laboratory studies show the development of torpidity to methotrexate therapy in subgroups of patients in both groups.  Thus, the use of anti-cytokine therapy is a major advance in the treatment of rheumatoid arthritis.

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Published

2024-04-01