A CHANGE IN THE GUT MICROBIOTA IS A FACTOR IN THE DEVELOPMENT OF GOUT IN HYPERURICEMIA
Abstract
Gout is a metabolic disease, the prevalence of which is growing worldwide and reaches 1-6% in developed countries (Shalnova S.A., 2014). Gout is characterized by chronic inflammation mediated by the presence of urate crystals (Nasonov E.L., 2016), the targets of which are not only the joints, but also the kidneys (Eliseev M.S., 2018) and the cardiovascular system (Singh J.A., 2014). The probability of detecting urate crystals in the gastrointestinal tract is very high, up to the formation of tofuses (Nasonova V.A., 2004). It was demonstrated (Chu Y, 2021) that the intestinal metagenome in gout was most similar in taxonomic structure, including analysis of 40 bacterial species, to that in ankylosing spondylitis (AS) and microbial functions to that in rheumatoid arthritis (RA) and AS. These data indicate that dysbiosis in gout is probably more consistent with dysbiosis in autoimmune diseases than in metabolic diseases. This suggests that the intestinal microbiota may have a general effect on immune processes.
References
Шальнова СА, Деев АД, Артамонова ГВ и др. Гиперурикемия и ее корреляты в Российской популяции (результаты эпидемиологического исследования ЭССЕРФ). Рациональная Фармакотерапия в Кардиологии. 2014;10 (2):153-9. [Shalnova SA, Deev AD, Artamonov GV, et al.
Hyperuricemia and its correlates in the Russian population (results of ESSE-RF epidemiological study). Ratsional'naya Farmakoterapiya v Kardiologii. 2014;10 (2):153-9.(InRuss.)].
Барскова ВГ, Елисеев МС, Денисов ИС и др. Частота метаболического синдрома и сопутствующих заболеваний у больных подагрой. Данные многоцентрового исследования. Научно-практическая ревматология. 2012;50(6):15-8. [Barskova VG, Eliseev MS, Denisov IS, et al. The rate of metabolic syndrome and comorbidities in patients with gout: data of a multicenter trial. Nauchno-prakticheskaya revmatologiya. 2012;50(6):15-8. (In Russ.)].
Елисеев МС, Выходец ИТ, Круглова ИВ и др. Распространенность гиперурикемии у профессиональных спортсменов и ее роль в генезе различных патологических состояний и обменных нарушений. Современная ревматология. 2018;12(3):82-8. [Eliseev MS, Vykhodets IТ, Kruglova IV, et al. Prevalence of hyperuricemia in professional athletes and its role in the genesis of various
pathological conditions and metabolic disturbances. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2018;12(3):82-8. (In Russ.)]. doi: 10.14412/1996-7012-
-3-82-88.
Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet. 2016 Oct 22;388(10055):2039-
doi:10.1016/S0140-6736(16)00346-9.
Mendez-Salazar EO, Martinez-Nava GA.Uric acid extrarenal excretion: the gut microbiome as an evident yet understated factor in gout development. Rheumatol Int.2022Mar;42(3):403-12.doi:10.1007/s00296-021-05007-x.
Salem F, Kindt N, Marchesi JR, et al. Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences. United European Gastroenterol J. 2019. Oct; 7(8):1008-32. doi: 10.1177/20506406 19867555. Epub 2019Aug1.
Yin J, Sternes PR, Wang M, et al. Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition. Ann Rheum Dis. 2020 Jan;79(1): 132-40. doi: 10.1136/annrheumdis-2019- 215763. Epub 2019 Oct 29.
Zhang X, Zhang D, Jiaet H, et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med. 2015 ug;21(8):895-905.doi:10.1038/nm.3914.
Scher JU, Ubeda C, Artachoet A, et al. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol. 2015 Jan; 67(1):128-39. doi: 10.1002/art.38892.
Chu Y, Sun S, Huang Y, et al. Metagenomic analysis revealed the potential role of gut microbiome in gout. NPJ Biofilms Microbiomes. 2021 Aug 9;7(1):66. doi: 10.1038/s41522-021-00235-2.
