TSIANOKOBALAMIN METABOLIZMI VA METFORMINTERAPIYA
Keywords:
qandli diabet, vitamin B12, holesterin, lipid spektr, metformin, inssulinrezistentlik, semizlik, tana vazni oshiqligiAbstract
Metformin qandli diabet 2 turini davolashda qo’llaniladigan asosiy biguanidlar guruhiga mansub preparatiir, qonda qand miqdorini pasaytiradi, insulinorezistentlikka qarshi ta’sirga ega, qon tomir patologiyasi va o'lim xavfini kamaytiradi, geroprotektiv ta'sir ko'rsatadi. Epidemiologik va randomizatsiyalangan tadqiqotlar shuni ko'rsatdiki, metformin bilan uzoq muddatli davolanish qonda B12 vitamini darajasining pasayishi xavfini oshiradi, bu diabetik periferik neyropatiyaning rivojlanishiga ta’sir etadi. Metformin qabul qiliish miqdori va davomiyligi katta ahamiyatga egadir. Shifokorlar metformin bilan davolanayotganlarda periferik neyropatiya rivojlanishini bartaraf etishda qonda cianokobalamin meyori nazoratini olib borishlari zarur va bemorlar ogoh bo’lishlari tavsiya etiladi.
References
Alston TA. Does metformin interfere with thiamine? Arch Intern Med 2003; 163 (8): 983.
Xu L, Huang Z, He X et al. Adverse effect of metformin therapy on serum vitamin B12 and folate: short-term treatment causes disadvantages? Med Hypotheses 2013; 81 (2): 149–51.
Buvat DR. Use of metformin is a cause of vitamin B12 deficiency. Am Fam Physician 2004; 69 (2): 264; author reply 26.
Громова О.А., Горшин И.Ю., Синергидные нейропротекторные эффекты тиамина, пиридоксина и цианокобаламина в рамках протеома человека. Неврология и ревматология (прил. к журн. Consilium Medicum). 2016; 2: 76–84. / Gromova O.A., Torshin I.Yu., Prokopovich O.A. Synergistic neuroprotective effects of thiamine, pyridoxine and cyanocobalamin within the human proteome. Neurology and Rheumatology (Suppl. Consilium Medicum). 2016; 2: 76–84. [in Russian]
Adams JF, Clark JS, Ireland JT et al. Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy. Diabetologia 1983; 24 (1): 16–8.
Muller P, Fischer H, Sorger D. Vitamin B12-level in serum of diabetics receiving long-term buformin therapy. Z Gesamte Inn Med 1981; 36 (6): 226–8.
Caspary WF, Zavada I, Reimold W et al. Alteration of bile acid metabolism and vitaminB12-absorption in diabetics on biguanides. Diabetologia 1977; 13 (3): 187–93.
Маев И.В., Самсонов А.А. Болезни двенадцатиперстной кишки. м.: медпресс-информ, 2005. / Maev I.V., Samsonov A.A. Bolezni dvenadtsatiperstnoi kishki. M.: MEDpress-inform, 2005. [in Russian]
Kapadia CR, Essandoh LK. Active absorption of vitamin B12 and conjugated bile salts by guinea pig ileum occurs in villous and not crypt cells. Dig Dis Sci 1988; 33 (11): 1377–82.
Tomkin GH. Comparison of the effect of parenteral with oral biguanide therapy on vitamin B12 and bile acid absorption. Ir J Med Sci 1976; 145 (1): 340.
Greibe E, Miller JW, Foutouhi SH et al. Metformin increases liver accumulation of vitamin B12 – an experimental study in rats. Biochimie 2013; 95 (5): 1062–5.
Obeid R, Jung J, Falk J et al. Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimie 2013; 95 (5): 1056–61.
Novelle M, Ali A, Diéguez C et al. Metformin: A Hopeful Promise in Aging Research. Cold Spring Harb Perspect Med 2016; 6 (3): a025932. DOI: 10.1101/cshperspect.a025932
Sahin M, Tutuncu NB, Ertugrul D et al. Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus. J Diabetes Complications 2007; 21 (2): 118–23.
Bauman WA, Shaw S, Jayatilleke E et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000; 23 (9): 1227–31.
Rufenacht P, Mach-Pascual S, Iten A. Vitamin B12 deficiency: a challenging diagnosis and treatment. Rev Med Suisse 2008; 4 (175): 2212–4, 2216–7.
Zdilla MJ. Metformin With Either Histamine H2-Receptor Antagonists or Proton Pump Inhibitors: A Polypharmacy Recipe for Neuropathy via Vitamin B12 Depletion. Clin Diabetes 2015; 33 (2): 90–5.
Damiao CP, Rodrigues AO, Pinheiro MF et al. Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study. Sao Paulo Med J 2016; 134 (6): 473–9.
Roy RP, Ghosh K, Ghosh M et al. Study of Vitamin B12 deficiency and peripheral neuropathy in metformin-treated early Type 2 diabetes mellitus. Indian J Endocrinol Metab 2016;
Andres E, Perrin AE, Demangeat C et al. The syndrome of food-cobalamin malabsorption revisited in a department of internal medicine. A monocentric cohort study of 80 patients. Eur J Intern Med 2003; 14 (4): 221–6.
Hansen CS, Jensen JS, Ridderstrale M et al. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes. J Diabetes Complications 2017; 31 (1): 202–8. 22. Moore E, Mander A, Ames D et al. Cognitive impairment and vitamin B12: a review. Int Psychogeriatr 2012; 24 (4): 541–56.
Mourits-Andersen T, Ditzel J. Megaloblastic anemia caused by malabsorption of vitamin B12 during long-term metformin therapy. Ugeskr Laeger 1983; 145 (1): 25–6.
Callaghan TS, Hadden DR, Tomkin GH. Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment. Br Med J 1980; 280 (6225): 1214–5.
Biemans E, Hart HE, Rutten GE et al. Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin. Acta Diabetol 2015; 52 (2): 383–93.
Ahmed MA, Muntingh G, Rheeder P. Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy. BMC Pharmacol Toxicol 2016; 17 (1): 44.
Damiao CP, Rodrigues AO, Pinheiro MF et al. Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study. Sao Paulo Med J 2016; Sao Paulo: S1516-318020160050.
Wulffele MG, Kooy A, Lehert P et al. Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med 2003; 254 (5): 455–63.
Kancherla V, Garn JV, Zakai NA et al. Multivitamin Use and Serum Vitamin B12 Concentrations in Older-Adult Metformin Users in REGARDS, 2003–2007. PLoS One 2016; 11 (8): e0160802.
Chapman LE, Darling AL, Brown JE. Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Metab 2016; 42 (5): 316–27.
Holmes D. Diabetes: Metformin linked to vitamin B12 deficiency. Nat Rev Endocrinol 2016; 12 (6): 312.
Aroda VR, Edelstein SL, Goldberg RB et al. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab 2016; 101 (4): 1754–61.
Liu Q, Li S, Quan H, Li J. Vitamin B12 status in metformin treated patients: systematic review. PLoS One 2014; 9 (6): e100379.
Niafar M, Hai F, Porhomayon J, Nader ND. The role of metformin on vitamin B12 deficiency: a meta-analysis review. Intern Emerg Med 2015; 10 (1): 93–102. O.A.Gromova et al. / Consilium Medicum. 2017; 19 (4): 58–64.
Parry-Strong A, Langdana F, Haeusler S et al. Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomised trial. N Z Med J 2016; 129 (1436): 67–75.
Beulens JW, Hart HE, Kuijs R et al. Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. Acta Diabetol 2015; 52 (1): 47–53.
Доскина е.в. диабетическая полинейропатия и в12-дефицитные состояния: основы патогенеза, пути лечения и профилактики. Фарматека. 2011; 20: 38–43. / Doskina E.V. Diabeticheskaia polineiropatiia i B12-defitsitnye sostoianiia: osnovy patogeneza, puti lecheniia i profilaktiki. Farmateka. 2011; 20: 38–43. [in Russian]
Панкратова ю.в. длительное лечение метформином пациентов с сахарным диабетом 2 типа и витамин в12: рандомизированное плацебо-контролируемое исследование. ожирение и метаболизм. 2012; 4: 56–7. / Pankratova Yu.V. Dlitel'noe lechenie metforminom patsientov s sakharnym diabetom 2 tipa i vitamin в12: randomizirovannoe platsebo-kontroliruemoe issledovanie. Ozhirenie i metabolizm. 2012; 4: 56–7. [in Russian]
Новиков В.И., Новиков К. Ю. Осложнения сахарного диабета: терапия от а до… В1, В6, В12. справочник поликлинического врача. 2015; 6–7: 56–9.
