ASSESSMENT OF POLYGENIC RISK OF ARTERIAL HYPERTENSION
Keywords:
arterial hypertension, genetic risk scale.Abstract
Arterial hypertension (AH) is a leading risk factor for the development of cardiovascular diseases. In recent decades, the rapid development of genetic research, in particular genome-wide association search (GWAS), has made it possible to identify hundreds of variants of the nucleotide sequence associated with the development of hypertension. One of the approaches to improving the predictive ability of genetic testing is to combine information about many variants of the nucleotide sequence into a single risk assessment system, often called the genetic risk scale. Within the framework of this review, the most significant publications on the study of the AH genetic risk scale will be considered, the features of their development and application will be discussed.
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